Gas-Phase Dissociation of Oligonucleotides
Oligonucleotides have great potential in diagnostic and therapeutic applications. Their high specificity offers promise for the development of new drugs for protein induced diseases. Several modifications were introduced in oligonucleotides to improve nuclease resistance, binding affinity and specificity. The various unnatural oligonucleotides are not compatible with the classical sequencing techniques. Therefore, new methods for fast and unambiguous sequence verification are ...